![]() Each of these two loops could be further divided in two segments. ![]() to the anterior papillary muscle) and the apical loop (from the beginning of the central fold to the root of the aorta). The central 180-degree fold of the HVMB defines two loops: the basal loop (from the root of the pulmonary artery to the beginning of the central foldi.e. The HVMB is topographically divided in two loops, each of them comprising of two segments (Figure 1E). Because one of the most important scientific missions in this century is integration of basic research with clinical medicine, we believe that this knowledge is not of merely academic importance, but is also the essential prerequisite in clinical evaluation and treatment of different heart diseases.Ī-D) depicts successive steps of dissection technique applied in unraveling the ventricular mass into HVMB. The primary purpose of this review is to emphasize the importance of this concept, in the light of collaborative efforts to establish an integrative approach, defining ventricular form and function by linking across multiple scales of biological organization, as explained in the ongoing Physiome project. ![]() This concept defines the principal, cumulative vectors, integrating the tissue architecture (ie, form) and net forces developed (ie, function) within the ventricular mass. The helical ventricular myocardial band of Torrent-Guasp is a revolutionary new concept in understanding global, 3-dimensional, functional architecture of the ventricular myocardium. ![]() Pronounced and practically indefinite global and local structural anisotropy of its fibers and other ventricular wall constituents produces electrical and mechanical properties that are nonlinear, anisotropic, time varying, and spatially inhomogeneous. Yet, ventricular myocardium has proven remarkably resistant to macroscopic analyses of functional anatomy. We live in an era of substantial progress in understanding myocardial structure and function at genetic, molecular, and microscopic levels. ![]()
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